This guide equips clinicians with information for treating chronic pain in adults living with a history of substance use. The guide discusses chronic pain management, including treatment with opioids. It also includes information about substance use assessments and referrals. Access the literature review.

This fact sheet describes ways to reduce the risks of taking methadone for pain relief or medication-assisted treatment of opioid use disorders. It lists methadone side effects that require emergency attention and offers resources for additional information.