This Clinical Guide provides comprehensive, national guidance for optimal management of pregnant and parenting women with opioid use disorder and their infants. The Clinical Guide helps healthcare professionals and patients determine the most clinically appropriate action for a particular situation and informs individualized treatment decisions.

This guide reviews child welfare, substance use disorder services, and courts to support cross-system coordination within state, county, and tribal jurisdictions. It considers the framework, population, legislation, funding sources, and services for each system.